Contact

End-stage liver disease

Introduction

End-stage liver disease (ESLD) covers a wide spectrum of pathologies, including:

  • acute liver failure without underlying chronic liver disease (ALF),
  • compensated advanced chronic liver disease (cACLD) and
  • decompensated cirrhosis,
    the latter may be chronic decompensation (CD) or acute decompensation (AD) with or without organ failure (acute on chronic liver failure, ACLF). In this context, bacterial infection is the most frequent trigger for acute decompensation and ACLF, and a frequent secondary complication in these patients.

Objectives

The research area aims to improve :

  • the identification of patients with end-stage liver disease (ESLD) who are at greatest risk of worsening their disease,
  • the diagnosis and prognosis of bacterial infections in ESLD, and
  • the diagnostic and prognostic stratification of patients with ESLD.

Strategy

Projects

No results found.

Publications

2025 Sep -

Critical Care Medicine Journal

Individual mHLA‑DR trajectories in the ICU as predictors of early infections following liver transplantation: a prospective observational study

G. Monneret, F. Lebossé et al.

Télécharger

2023 Jul -

iScience

PMID : 37575179

Circulating microRNAs improve bacterial infection diagnosis and overall survival prediction in acute decompensation of liver cirrhosis

Chouik et al.

Télécharger

Make a donation is above all
speeding up research

Make a donation

Other areas of research

Viral Liver Disease

Viral liver diseases are caused by 5 main types of viruses (A, B, C, D and E). Although these viruses all cause liver disease, the severity, course and treatments depend on the virus.
Find out more

Liver Metabolism – MASLD

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most widespread chronic liver disease and continues to increase.
Find out more

Addiction and the liver

Liver diseases linked to addiction (alcohol, drug use) represent a major public health issue. Understanding, treating and developing appropriate treatments requires specific support for these often vulnerable patients.
Find out more

Hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide. The majority of HCCs are associated with chronic liver disease due to chronic viral hepatitis, excessive alcohol consumption or metabolic disease.
Find out more

Liver transplantation

Liver transplantation is a complex and potentially life-saving operation that can cure serious liver diseases. Liver transplantation is the only solution in cases of liver failure.
Find out more
Centre intégré des maladies du foie
Contact
Email : contact@ihu-hepatolyon.fr
bluesky
Linkedin
youtube_2

Support IHU

Institut d’hépatologie de Lyon, 2023